Significance analysis of time course microarray experiments
نویسندگان
چکیده
منابع مشابه
Significance analysis of time course microarray experiments.
Characterizing the genome-wide dynamic regulation of gene expression is important and will be of much interest in the future. However, there is currently no established method for identifying differentially expressed genes in a time course study. Here we propose a significance method for analyzing time course microarray studies that can be applied to the typical types of comparisons and samplin...
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In this article we propose two practical types of designs for large time-course, dual-channel microarray experiments. One type consists of several interwoven loops, and the other type combines reference and loop designs. By representing the experiment as a graph, where the timepoints are nodes and the arrays are edges, we demonstrate how the time contrasts between any two timepoints can be esti...
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Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, agricultural and pharmaceutical sciences. There are myriad sources of uncertainty in microarray experiments, and rigorous experimental design is essential for fully realizing the potential ...
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In this paper we present a functional Bayesian method for detecting genes which are temporally differentially expressed between several conditions. We identify the nature of differential expression (e.g., gene is differentially expressed between the first and the second sample but is not differentially expressed between the second and the third) and subsequently we estimate gene expression temp...
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A truly functional Bayesianmethod for detecting temporally differentially expressed genes between two experimental conditions is presented. The method distinguishes between two biologically different set ups, one in which the two samples are interchangeable, and one in which the second sample is a modification of the first, i.e. the two samples are non-interchangeable. This distinction leads to...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0504609102